Efficacy and safety of direct oral anticoagulants in pediatric congenital and acquired heart disease: a systematic review and meta-analysis of randomized controlled trials

Abstract Background Children with congenital and acquired heart disease (CAHD) are at high risk for venous thromboembolism (VTE). Traditional anticoagulants such as vitamin K antagonists (VKAs) and low-molecular-weight heparin (LMWH) present challenges in pediatrics due to burdensome administration,...

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Detalhes bibliográficos

Principais autores:	Hanan El-Sayed Bakry, Mai Ibrahim Abdellah, Hani Abdelshafook Khalaf, Ahmed Ali Assem, Mohamad Mahmoud ElGamal, Mohamed Ibrahim Abdo, Mohamed Hamouda Elkasaby, Atef A. Hassan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Thrombosis Journal
Assuntos:	Apixaban, Congenital heart disease Direct oral anticoagulants Dabigatran, Edoxaban Rivaroxaban
Acesso em linha:	https://doi.org/10.1186/s12959-026-00850-z
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