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High-throughput screening of EGFR/Ca2+ signaling modulators in cardiac hypertrophy using a tetrahedral DNA nanostructure-based hESC platform

Cardiac hypertrophy, a precursor to heart failure (HF), involves intricate signaling networks characterized by epidermal growth factor receptor (EGFR) activation and calcium (Ca2+) dysregulation. Therapeutic inhibition of EGFR has emerged as a promising approach to attenuate maladaptive hypertrophic...

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Principais autores: Ke-Jia Wu, Yan-Fa Dai, Zhi-Qiang Wang, Wen Sun, Ya-Nan Zhu, Fan Chen, Ling Shao, Yao-Ye Huang, Qi Chen, Xin Liu, Yan Li, Hui-Min David Wang, Ning Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-04-01
coleção:Journal of Pharmaceutical Analysis
Assuntos:
Tetrahedral DNA nanostructures
High-throughput screening
Cardiac hypertrophy
EGFR
Calcium signaling
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095177925002965
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