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Novel 1,4-Naphthoquinone-Zidovudine Hybrid: Design, Synthesis, and <i>In Vitro</i> Evaluation of Its Anti-Trypanosomatid and Cytotoxic Activities

This work reports the synthesis and characterization of a new molecular hybrid <b>4</b>, created by combining 1,4-naphthoquinone with the drug zidovudine (AZT) through an azide-alkyne cycloaddition reaction catalyzed by Cu<sup>1+</sup>. <i>In vitro</i> studies assessed the anti-trypanosomatid activi...

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Principais autores: Thiago de Souza Dias Silva, Afonso Santine M. M. Velez, Tiago Ribeiro Rodriguez, João Vitor da Costa Silva, Henrique Previtalli-Silva, Flávia de Oliveira Cardoso, Célio Geraldo Freire-de-Lima, Otávio Augusto Chaves, Debora Decote-Ricardo, Marco Edilson Freire de Lima
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2026-01-01
סדרה:Chemistry
נושאים:
neglected tropical diseases
antiparasitic chemotherapy
molecular hybridization
1,2,3-triazole
CuAAC
גישה מקוונת:https://www.mdpi.com/2624-8549/8/2/15
תגים: הוספת תג
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