An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies

Bispecific antibodies have gained increasing popularity as therapeutics as they enable novel activities that cannot be achieved with monospecific antibodies. Some of the most popular bispecific formats are molecules in which two Fab arms with different antigen specificities are combined into one IgG...

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Principais autores:	Yinghui Rong, I-Ling Chen, Lance Larrabee, Manali S. Sawant, Germaine Fuh, Patrick Koenig
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-02-01
Colecção:	Antibodies
Assuntos:	antibody discovery genetically engineered mouse model common light chain bispecific antibodies
Acesso em linha:	https://www.mdpi.com/2073-4468/13/1/14
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