Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes

Objective: Chronic inflammation and oxidative stress mediate the pathological progression of diabetic complications, like diabetic retinopathy (DR), peripheral neuropathy (DPN) and impaired wound healing. Studies have shown that treatment with a stable form of arginase 1 that reduces l-arginine leve...

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Detalhes bibliográficos

Principais autores:	Ammar A. Abdelrahman, Porsche V. Sandow, Jing Wang, Zhimin Xu, Modesto Rojas, John S. Bomalaski, Tahira Lemtalsi, Ruth B. Caldwell, Robert W. Caldwell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-11-01
coleção:	Molecular Metabolism
Assuntos:	Diabetic complications Arginase 1 Arginine deiminase Visual function Anti-inflammatory l-arginine
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877824001510
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