A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior

Adversity early in life substantially impacts prefrontal cortex (PFC) development and vulnerability to later-life psychopathology. Importantly, repeated adverse experiences throughout childhood increase the risk for PFC-mediated behavioral deficits more commonly in women. Evidence from animal models...

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Bibliografske podrobnosti

Principais autores:	Kelsea R. Gildawie, Lilly M. Ryll, Jessica C. Hexter, Shayna Peterzell, Alissa A. Valentine, Heather C. Brenhouse
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2021-04-01
Serija:	Developmental Cognitive Neuroscience
Teme:	Maternal separation Prefrontal cortex Perineuronal nets Parvalbumin Sex differences Anxiety
Online dostop:	http://www.sciencedirect.com/science/article/pii/S1878929321000153
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