A novel probe to assess cytosolic entry of exogenous proteins
The mechanism of protein dislocation into the cytosol during antigen cross-presentation is poorly understood. Here the authors engineer a dislocation reporter fusing a glycosylated luciferase variant to the Fc region of IgG1, and find that dislocation is the rate limiting step in cross-presentation.
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2018-08-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-018-05556-z |
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