Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization

Abstract Ferroptosis, a form of cell death instigated by iron-dependent lipid peroxidation reactions (LPO), is emerging as a promising therapeutic target for cancer. While the mechanisms governing LPO induction and suppression have gradually been unveiled, questions persist regarding the specific ce...

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Detalles Bibliográficos

Principais autores:	Yuma Saimoto, Daiki Kusakabe, Kazushi Morimoto, Yuta Matsuoka, Eisho Kozakura, Nao Kato, Kayoko Tsunematsu, Tomohiro Umeno, Tamiko Kiyotani, Shota Matsumoto, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa, Koji Uchida, Satoru Karasawa, Mirinthorn Jutanom, Ken-ichi Yamada
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-04-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-58909-w
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