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Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood

Lymphotoxin beta receptor (LTβR) is a promising therapeutic target in autoimmune and infectious diseases as well as cancer. Mice with genetic inactivation of LTβR display multiple defects in development and organization of lymphoid organs, mucosal immune responses, IgA production and an autoimmune p...

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Principais autores: Yajun Shou, Ekaterina Koroleva, Cody M. Spencer, Sergey A. Shein, Anna A. Korchagina, Kizil A. Yusoof, Raksha Parthasarathy, Elizabeth A. Leadbetter, Armen N. Akopian, Amanda R. Muñoz, Alexei V. Tumanov
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-07-01
Serier:Frontiers in Immunology
Fag:
lymphotoxin
LTβR
lymphoid organs
FDCs
IgA
Citrobacter rodentium
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712632/full
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