In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19

Conventional drug screening methods search for a limited number of small molecules that directly interact with the target protein. This process can be slow, cumbersome and has driven the need for developing new drug screening approaches to counter rapidly emerging diseases such as COVID-19. We propo...

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Bibliographic Details

Main Authors:	Takaharu Asano, Sarvesh Chelvanambi, Julius L. Decano, Mary C. Whelan, Elena Aikawa, Masanori Aikawa
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	L1000 connectivity map (CMap) ACE2 COVID-19 drug repurposing lung epithelial cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.842641/full
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