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Divergent immune and extracellular matrix transcriptional programs underlie poor prognosis in early-stage lung adenocarcinoma

BackgroundEarly-stage lung adenocarcinoma (LUAD) patients with similar pathological stage exhibit heterogeneous recurrence risk. Prior work suggested that intra-tumoral immune composition, particularly B cells, regulatory T cells, and macrophages stratify recurrence outcomes. These immune programs o...

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Autor principal: Jyothi Thyagabhavan Mony
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-04-01
coleção:Frontiers in Immunology
Assuntos:
early-stage lung adenocarcinoma
gene expression networks
immune-extracellular matrix interactions
overall survival
prognostic biomarkers
recurrence risk
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1762224/full
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