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Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers

ABSTRACT Introduction Narcolepsy Type 1 (NT1) is a chronic neurological disorder characterized by excessive daytime sleepiness (EDS), cataplexy, and REM intrusions, caused by a deficiency of orexin (hypocretin), a hypothalamic neuropeptide essential for arousal, REM sleep regulation, metabolism, and...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Rameesha Rauf, Salwa Asif, Abdallah AlSaafeen, Kaviprada Geathaa Dhantapaani, Maryam Muhammad Nadeem, Zohra Kamran Rao, Aliya Shaju Shahul Hameed, Karthik Chintharala, Muhammad Faheem Anwar, Asad Ali Ahmed Cheema
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2025-10-01
Schriftenreihe:Brain and Behavior
Schlagworte:
autoimmune neurodegeneration
hypocretin
narcolepsy Type 1
orexin deficiency
sleep–wake regulation
therapeutic targets
Online-Zugang:https://doi.org/10.1002/brb3.70984
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