Re-Programming Autoreactive T Cells Into T-Regulatory Type 1 Cells for the Treatment of Autoimmunity

Systemic delivery of peptide-major histocompatibility complex (pMHC) class II-based nanomedicines can re-program cognate autoantigen-experienced CD4+ T cells into disease-suppressing T-regulatory type 1 (TR1)-like cells. In turn, these TR1-like cells trigger the formation of complex regulatory cell...

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Autors principals:	Patricia Solé, Pere Santamaria
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-07-01
Col·lecció:	Frontiers in Immunology
Matèries:	T-regulatory type 1 (TR1) cells peptide-MHC class II-coated nanoparticles T-cell reprogramming interleukin 10 (IL10) autoimmune disease therapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.684240/full
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