Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

Abstract Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of Aβ and this binding modulates Aβ accum...

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Bibliografische gegevens

Hoofdauteurs:	Shan Liu, Shinae Park, Grant Allington, Frances Prelli, Yanjie Sun, Mitchell Martá-Ariza, Henrieta Scholtzova, Goutam Biswas, Bernard Brown, Philip B. Verghese, Pankaj D. Mehta, Yong-Uk Kwon, Thomas Wisniewski
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Portfolio 2017-08-01
Reeks:	Scientific Reports
Online toegang:	https://doi.org/10.1038/s41598-017-08604-8
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