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The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis

Low-density lipoprotein receptor–related protein-1 (LRP1) is a large endocytic and signaling receptor belonging to the LDL receptor (LDLR) gene family and that is widely expressed in several tissues. LRP1 comprises a large extracellular domain (ECD; 515 kDa, α chain) and a small intracellular domain...

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Principais autores: Jiefang Chen, Ying Su, Shulan Pi, Bo Hu, Ling Mao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-05-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
LRP1
atherosclerosis
smooth muscle cells
macrophages
endothelial cells
adipocytes
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcvm.2021.682389/full
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