Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC

In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classi...

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Detalhes bibliográficos
Main Authors: Steffen Löck, Lydia Koi, Kristin Gurtner, Fabian Lohaus, Max Kemper, Dominik Haim, Inge Tinhofer, Goda Kalinauskaite, Martin Stuschke, Maximilian Fleischmann, Claus Rödel, Anca-Ligia Grosu, Jürgen Debus, Claus Belka, Stephanie Combs, Simon Boeke, Gustavo Baretton, Michael Baumann, Mechthild Krause, Annett Linge
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-01-01
Colecção:Clinical and Translational Radiation Oncology
Assuntos:
Head and Neck Cancer
Gene signature
Xenograft models
Outcome Prediction
Cetuximab
EGFR
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405630825001594
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