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Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer

Abstract Overcoming the lysosomal entrapment of nanotherapeutics remains a pivotal challenge for efficient drug delivery. Herein, we developed a nano-delivery system, designated as CEL-TPP@siSurvivin/TDNP NPs, consisting of a self-assembled nanocore formed by triphenylphosphine (TPP)-modified celast...

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Hlavní autoři: Keyao Liu, Tingting Xiong, Xueyuan Wang, Ting Wang, Yudi Wang, Meng Lei, Lihua Shao, Liefeng Zhang, Yongqiang Zhu
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2026-03-01
Edice:Journal of Nanobiotechnology
Témata:
siSurvivin
Lysosomal escape
V-ATPase
Plant exosomes
Combination therapy
On-line přístup:https://doi.org/10.1186/s12951-026-04311-7
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