Disulfide tethering reveals cryptic pockets in oncogenic KRAS

Abstract Disulfide tethering is a site-directed method of drug discovery used to identify hits for challenging targets. We applied tethering to target oncogenic KRAS, a small GTPase once considered undruggable due to its high nucleotide affinity and a perceived absence of binding sites. We prepared...

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Principais autores:	Trent E. Balius, Marcin Dyba, Vandana Kumari, John-Paul Denson, Ming Yi, Alok K. Sharma, Priyanka Prakash, Emily Alberico, Simon Messing, Vanessa Wall, Albert H. Chan, Dhirendra K. Simanshu, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Anna E. Maciag, David M. Turner
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2026-03-01
叢編:	Communications Chemistry
在線閱讀:	https://doi.org/10.1038/s42004-026-01992-x
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