Novel Trimethoprim-Based Metal Complexes and Nanoparticle Functionalization: Synthesis, Structural Analysis, and Anticancer Properties

In this study, we synthesized a novel trimethoprim derivative, 4-(((2-amino-5-(3,4,5-trimethoxybenzyl) pyrimidine-4-yl)imino)methyl)benzene-1,3-diol (HD), by the reaction of trimethoprim with 2,4-dihydroxybenzaldehyde. We then prepared metal complexes of this derivative with Cu(II), Co(II), Ni(II),...

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Autors principals:	Abbas M. Abbas, Hossam H. Nasrallah, A. Aboelmagd, W. Christopher Boyd, Haitham Kalil, Adel S. Orabi
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-05-01
Col·lecció:	Inorganics
Matèries:	trimethoprim metal complexes ZnO and Au nanoparticles anticancer DFT docking
Accés en línia:	https://www.mdpi.com/2304-6740/13/5/144
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