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Integrative single-cell RNA-seq and transcriptomic analysis uncovers cellular heterogeneity and immunotherapy resistance mechanisms in colorectal cancer

Abstract Objective To investigate the molecular and cellular features associated with immunotherapy resistance in colorectal cancer (CRC) and identify potential biomarkers. Methods The single-cell RNA sequencing data from 14 pre-treatmant CRC samples (11 complete respondence and 3 stable disease) we...

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Principais autores: Yirou Wang, Yingying Zhang, Ziyong Mao, Wenle Du, Xiyuan Cao, Minxuan Jiang, Qingchen Zhang, Shenghua Zhan, Zutao Chen
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2026-05-01
Serier:Discover Oncology
Fag:
Colorectal cancer (CRC)
Immunotherapy resistance
Tumor microenvironment (TME)
Single-cell RNA sequencing
Prognostic biomarker
Online adgang:https://doi.org/10.1007/s12672-026-05284-7
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