Safeguarding Lysosomal Homeostasis by DNAJC5/CSPα-Mediated Unconventional Protein Secretion and Endosomal Microautophagy

Neuronal ceroid lipofuscinosis (NCL) is a collection of genetically inherited neurological disorders characterized by vision loss, seizure, brain death, and premature lethality. At the cellular level, a key pathologic hallmark of NCL is the build-up of autofluorescent storage materials (AFSM) in lys...

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Hlavní autoři:	Juhyung Lee, Yue Xu, Yihong Ye
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-05-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	DNAJC5/CSPα cysteine string protein ceroid lipofuscinosis neuronal lysosome endosomal microautophagy misfolding-associated protein secretion (MAPS)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2022.906453/full
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