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Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Cancer risk after ionizing radiation (IR) is assumed to be linear with the dose; however, for low doses, definite evidence is lacking. Here, using temporal multi-omic systems analyses after a low (LD; 0.1 Gy) or a high (HD; 1 Gy) dose of X-rays, we show that, although the DNA damage response (DDR) d...

Ausführliche Beschreibung

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Hauptverfasser: Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J. Boei, Tanveer S. Batth, Jer-Gung Chang, Michelle T. Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel S. Olie, Bart Everts, Alfred C. O. Vertegaal, Jesper V. Olsen, Mats Ljungman, Penny A. Jeggo, Leon H. F. Mullenders, Harry Vrieling
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-11-01
Schriftenreihe:Cells
Schlagworte:
ionizing radiation
low dose
linear no-threshold
signal transduction
cell signaling
DNA damage response
Online-Zugang:https://www.mdpi.com/2073-4409/11/23/3794
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