Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage

Summary: E2F transcription factors control the expression of cell-cycle genes. Cancers often demonstrate enhanced E2F target gene expression, which can be explained by increased percentages of replicating cells. However, we demonstrate in human cancer biopsy specimens that individual neoplastic cell...

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Detalhes bibliográficos

Principais autores:	Hendrika A. Segeren, Lotte M. van Rijnberk, Eva Moreno, Frank M. Riemers, Elsbeth A. van Liere, Ruixue Yuan, Richard Wubbolts, Alain de Bruin, Bart Westendorp
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-12-01
coleção:	Cell Reports
Assuntos:	cell cycle anaphase-promoting complex/cyclosome E2F transcription live-cell imaging single-cell RNA sequencing DNA damage
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124720314388
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