Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

Background: Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response rates are low. Clinical trials lack the power to study the genetic contribution to SSRI response. Real-world evidence from electronic health...

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Autori principali:	Chris Wai Hang Lo, Alexandra C. Gillett, Matthew H. Iveson, Michelle Kamp, Chiara Fabbri, Win Lee Edwin Wong, Dale Handley, Oliver Pain, Evangelos Vassos, Naomi R. Wray, Heather C. Whalley, Danyang Li, Allan H. Young, Andrew M. McIntosh, Cathryn M. Lewis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-07-01
Serie:	Biological Psychiatry Global Open Science
Soggetti:	Antidepressant response Electronic health records Generation Scotland GWAS Selective serotonin reuptake inhibitors (SSRIs) UK Biobank
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2667174325000564
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