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CNS efficacy of afatinib as first-line treatment in advanced non-small cell lung cancer patients with EGFR mutations

BackgroundAfatinib is a potent, irreversible second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor which has demonstrated efficacy in advanced non-small cell lung cancer (NSCLC) patients harboring either common or uncommon EGFR mutations. However, data on its activity a...

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Principais autores: Liping Kang, Jianliang Mai, Weiting Liang, Qihua Zou, Caiwen Huang, Yongbin Lin, Ying Liang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-02-01
Serier:Frontiers in Oncology
Fag:
NSCLC
afatinib
brain metastases
CNS efficacy
uncommon EGFR mutations
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2023.1094195/full
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