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Enhanced induction of fetal hemoglobin by the combination of decitabine with RN-1 in β-thalassemia/HbE erythroid progenitor cells

Abstract Background Fetal hemoglobin (HbF; α2γ2) induction is a well-established approach for β-hemoglobinopathies, including sickle cell disease (SCD) and β-thalassemia. Decitabine, a DNA methyltransferase 1 (DNMT1) inhibitor, has been shown to effectively induce HbF production with a favorable saf...

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Principais autores: Tiwaporn Nualkaew, Phitchapa Pongpaksupasin, Thongperm Munkongdee, Nattrika Buasuwan, Kittiphong Paiboonsukwong, Orapan Sripichai, James Douglas Engel, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-01-01
Serier:Molecular Medicine
Fag:
Fetal hemoglobin induction
β-thalassemia/HbE
Decitabine
RN-1
Combination treatment
Online adgang:https://doi.org/10.1186/s10020-026-01421-8
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