A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

Mutations in <i>the leucine-rich repeat kinase-2 (LRRK2)</i> gene cause autosomal-dominant Parkinson’s disease (PD) and contribute to sporadic PD. Common genetic variation in LRRK2 modifies susceptibility to immunological disorders including Crohn’s disease and leprosy. Previous studies have reporte...

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Hauptverfasser:	Tianxia Li, Bo Ning, Lingbo Kong, Bingling Dai, Xiaofei He, Joseph M. Thomas, Akira Sawa, Christopher A. Ross, Wanli W. Smith
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-02-01
Schriftenreihe:	Cells
Schlagworte:	LRRK2 GTP binding inhibitor LPS TNF-α lymphoblast Parkinson’s disease
Online-Zugang:	https://www.mdpi.com/2073-4409/10/2/480
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