Bioequivalence of budesonide/glycopyrrolate/formoterol fumarate with a next-generation propellant versus hydrofluoroalkane-134a in healthy adults: phase I, randomized, double-blind, single-dose, partial-replicate, three-way cross-over lung exposure and total systemic exposure studies

Background: Hydrofluoroolefin-1234ze (HFO-1234ze) is a next-generation propellant with 99.9% lower global warming potential (GWP) than hydrofluoroalkane-134a (HFA-134a). Objectives: We report systemic and lung exposure bioequivalence for budesonide/glycopyrrolate/formoterol fumarate (BGF) components...

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Autori principali:	Artur Bednarczyk, Magnus Aurivillius, Mandeep Jassal, Mihir Shah, Ibrahim Raphiou, David Petullo, John Xu, Maria Heijer, Klementyna Sychowicz, Kathryn Collison, Carlos Silva, Jitendar Reddy, David Han, Ronald Goldwater, Michael Gillen, Mehul Patel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	SAGE Publishing 2026-02-01
Serie:	Therapeutic Advances in Respiratory Disease
Accesso online:	https://doi.org/10.1177/17534666261417149
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