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Broad innate immune activation enhances the protective efficacy of rBCG-LTAK63 against Mycobacterium tuberculosis

IntroductionTuberculosis (TB) continues to be one of the leading infectious causes of mortality world-wide, while the Bacillus Calmette–Guérin (BCG) vaccine provides variable protection. To address this limitation, our group developed a recombinant BCG strain expressing a detoxified Escherichia coli...

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Hlavní autoři: Ana Carolina de Oliveira Carvalho, Monalisa Martins Trentini, Dunia Rodriguez, Lázaro Moreira Marques-Neto, Paulo Henrique Santana Silveira, Nancy Starobinas, Sergio Costa Oliveira, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-03-01
Edice:Frontiers in Immunology
Témata:
BCG vaccine
inflammasome
innate immunity
rBCG-LTAK63
recombinant BCG
tuberculosis
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1758476/full
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