Conversion of RpoS⁻ Attenuated <named-content content-type="genus-species">Salmonella enterica</named-content> Serovar Typhi Vaccine Strains to RpoS⁺ Improves Their Resistance to Host Defense Barriers

ABSTRACT The vast majority of live attenuated typhoid vaccines are constructed from the Salmonella enterica serovar Typhi strain Ty2, which is devoid of a functioning alternative sigma factor, RpoS, due to the presence of a frameshift mutation. RpoS is a specialized sigma factor that plays an import...

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Principais autores:	Whittney N. Burda, Karen E. Brenneman, Amanda Gonzales, Roy Curtiss
格式:	Artigo
语言:	Inglês
出版:	American Society for Microbiology 2018-02-01
丛编:	mSphere
主题:	RASV RpoS S. Typhi vaccines Salmonella recombinant
在线阅读:	https://journals.asm.org/doi/10.1128/mSphere.00006-18
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