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Developing therapeutic strategies to target MCL1 and BCLXL in lethal prostate cancer

Summary: Targeting anti-apoptotic BCL2 family proteins is an attractive therapeutic strategy to drive prostate cancer (PCa) cell death. Here, we show that MCL1 is highly expressed in castration-resistant PCa, associating with worse clinical outcome. We demonstrate that targeting MCL1 with BH3 mimeti...

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Автори: Daniel Westaby, Juan M. Jiménez-Vacas, Ines Figueiredo, Jonathan Welti, Bora Gurel, Denisa Bogdan, Lorenzo Buroni, Antje J. Neeb, Jan Rekowski, Ana Padilha, Souvik Das, Joe Taylor, Wanting Zeng, Nick Waldron, Thomas Goldsmith, Emily Hobern, Florian Gabel, Nicole Pandell, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Amanda Swain, Wei Yuan, Steven P. Balk, Marco Bezzi, Johann S. de Bono, Adam Sharp
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2025-12-01
Серія:iScience
Предмети:
Pharmacology
molecular biology
cancer
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2589004225022461
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