Synthesis of Proposed Structure of Aaptoline B via Transition Metal-Catalyzed Cycloisomerization and Evaluation of Its Neuroprotective Properties in <i>C. Elegans</i>

A concise synthesis of the proposed structure of aaptoline B, a pyrroloquinoline derived from a marine sponge, was accomplished. A key feature of this synthesis is the versatile transition metal-catalyzed cycloisomerization of <i>N</i>-propargylaniline to construct a quinoline skeleton. However, the...

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Principais autores:	Soobin Kim, Wooin Yang, Young-Taek Han, Dong-Seok Cha
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-09-01
Series:	Applied Sciences
Assuntos:	aaptoline B pyrroloquinoline Ag(I)-catalyzed cycloisomerization dopaminergic neuroprotection Parkinson’s disease
Acceso en liña:	https://www.mdpi.com/2076-3417/11/19/9125
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