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Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury

Abstract Background Muscle denervation from trauma and motor neuron disease causes disabling morbidities. A limiting step in functional recovery is the regeneration of neuromuscular junctions (NMJs) for reinnervation. Stem cells have the potential to promote these regenerative processes, but current...

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Autori principali: LeeAnn K. Li, Wen-Chin Huang, Yuan-Yu Hsueh, Ken Yamauchi, Natalie Olivares, Raul Davila, Jun Fang, Xili Ding, Weikang Zhao, Jennifer Soto, Mahdi Hasani, Bennett Novitch, Song Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-05-01
Serie:Stem Cell Research & Therapy
Soggetti:
Neural crest stem cell
Spheroid
Neuromuscular junction
Tissue engineering
Peripheral nerve injury
Regenerative medicine
Accesso online:https://doi.org/10.1186/s13287-022-02877-1
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