In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott–Aldrich Syndrome Protein-Deficient B Cells

Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency caused by mutations in the gene encoding the hematopoietic-specific WAS protein (WASp). WAS is frequently associated with autoimmunity, indicating a critical role of WASp in maintenance of tolerance. The role of B cells in the induction of...

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Principais autores:	Anna Villa, Marita Bosticardo, Maria Carmina Castiello, Francesca Pala, Lucia Sereni, Elena Draghici, Donato Inverso, Aisha V. Sauer, Francesca Schena, Elena Fontana, Enrico Radaelli, Paolo Uva, Karla E. Cervantes-Luevano, Federica Benvenuti, Pietro L. Poliani, Matteo Iannacone, Elisabetta Traggiai
格式:	Artigo
语言:	Inglês
出版:	Frontiers Media S.A. 2017-05-01
丛编:	Frontiers in Immunology
主题:	Wiskott–Aldrich syndrome autoimmunity B cells toll-like receptors apoptotic cells lymphocytic choriomeningitis virus
在线阅读:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00490/full
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