A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression.

There is an urgent and unmet need for accurate biomarkers in Amyotrophic Lateral Sclerosis. A pharmaco-metabolomics study was conducted using plasma samples from the TRO19622 (olesoxime) trial to assess the link between early metabolomic profiles and clinical outcomes. Patients included in this tria...

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Hlavní autoři:	Hélène Blasco, Franck Patin, Amandine Descat, Guillaume Garçon, Philippe Corcia, Patrick Gelé, Timothée Lenglet, Peter Bede, Vincent Meininger, David Devos, Jean François Gossens, Pierre-François Pradat
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2018-01-01
Edice:	PLoS ONE
On-line přístup:	https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198116/1/pone.0198116.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210223%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210223T052556Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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