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Placental transfer of third-generation antiepileptic drugs: in vivo lacosamide case study and in vitro investigation of transporter inhibition by lacosamide and perampanel

Abstract Background Antiepileptic drugs must be continually used to control seizures in pregnant people with epilepsy. Lacosamide (LCM) and perampanel (PER) are third-generation antiepileptic drugs that were introduced to clinical practice in 2008 and 2012, respectively. LCM and PER are increasingly...

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Autori principali: Ayami Ueda, Ayako Furugen, Ayako Nishimura, Takeshi Umazume, Ryoichi Aoyagi, Keisuke Okamoto, Katsuya Narumi, Hinata Ueda, Masaki Kobayashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-01-01
Serie:Journal of Pharmaceutical Health Care and Sciences
Soggetti:
Antiepileptic drugs
Lacosamide
Perampanel
Pregnancy
Placenta
Syncytiotrophoblast
Accesso online:https://doi.org/10.1186/s40780-025-00537-z
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