Spatially resolved ex vivo drug response profiling in SMARCB1-deficient sinonasal carcinoma

Abstract SMARCB1-deficient sinonasal carcinoma (SDSC) is a rare, highly aggressive malignancy with limited therapeutic options and no established preclinical models. Here, single-nucleus RNA sequencing (snRNAseq), spatial transcriptomics, and ex vivo patient-derived tissue slice culture (TSC) were c...

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Egile Nagusiak:	Philipp Jurmeister, Susanne Flach, Linda Bergmayr, Konstanze Schleich, Edgar Chimal Calderon, Liliana H Mochmann, Yauheniya Zhdanovich, Doreen Klingler, Ada Pusztai, Anna Kübler, Christoph Walz, Christoph Benedikt Westphalen, Alexander Beck, Maximilian Leitheiser, Gerben E Breimer, Johannes A Rijken, Lot Devriese, Philipp Baumeister, Alena Skálová, Simon Schallenberg, Frederick Klauschen, Andreas Mock
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Springer Nature 2026-05-01
Saila:	EMBO Molecular Medicine
Sarrera elektronikoa:	https://doi.org/10.1038/s44321-026-00437-1
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