ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process

Abstract Background Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with regards to the integrin-related mechanosensitive signaling pathway. We have previously reported that the silencing of ex...

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Hauptverfasser:	David Gagné, Yannick D. Benoit, Jean-François Groulx, Pierre H. Vachon, Jean-François Beaulieu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2020-03-01
Schriftenreihe:	BMC Molecular and Cell Biology
Schlagworte:	ILK IPP complex Integrin α5β1 RhoA Fibronectin
Online-Zugang:	http://link.springer.com/article/10.1186/s12860-020-00259-0
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