Profiling of BDQ-induced transcriptome suggests amino acid metabolism and stress responses as alternate mechanisms contributing to BDQ tolerance in Mycobacterium tuberculosis

ABSTRACT Under bedaquiline (BDQ) pressure, a temporary persistence period (24–96 h) has been observed, during which H37Rv undergoes metabolic rerouting. However, little is known of transcriptomic changes in BDQ-resistant Mycobacterium tuberculosis (Mtb) isolates during this period. We explored trans...

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Bibliographic Details

Main Authors:	Dania Khalid Saeed, Sadia Shakoor, Javaria Ashraf, Zahra Hasan, Rumina Hasan
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2026-02-01
Series:	Microbiology Spectrum
Subjects:	Mycobacterium tuberculosis metabolic fluxes stress pathways BDQ-induced transcriptional changes bedaquiline resistance
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.01455-25
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