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Conditional protein splicing of the Mycobacterium tuberculosis RecA intein in its native host

Abstract The recA gene, encoding Recombinase A (RecA) is one of three Mycobacterium tuberculosis (Mtb) genes encoding an in-frame intervening protein sequence (intein) that must splice out of precursor host protein to produce functional protein. Ongoing debate about whether inteins function solely a...

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Principais autores: Ryan F. Schneider, Kelly Hallstrom, Christopher DeMott, Kathleen A. McDonough
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-09-01
Serier:Scientific Reports
Fag:
Gene expression
Post-translational gene regulation
SOS response
DNA damage repair
Mobile elements
Exaptation
Online adgang:https://doi.org/10.1038/s41598-024-71248-y
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