Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction
Our examination of RNA helicases for effects on HIV-1 protein production and particle assembly identified Rocaglamide (RocA), a known modulator of eIF4A1 function, as an inhibitor of HIV-1 replication in primary CD4<sup>+</sup> T cells and three cell systems. HIV-1 attenuation by low-nM RocA doses w...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
MDPI AG
2024-09-01
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| Seria: | Viruses |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.mdpi.com/1999-4915/16/9/1506 |
| Etykiety: |
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