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Comparison of In-Frame Deletion, Homology-Directed Repair, and Prime Editing-Based Correction of Duchenne Muscular Dystrophy Mutations

Recent progress in CRISPR gene editing tools has substantially increased the opportunities for curing devastating genetic diseases. Here we compare in-frame deletion by CRISPR-based non-homologous blunt end joining (NHBEJ), homology-directed repair (HDR), and prime editing (PE, PE2, and PE3)-based c...

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Wedi'i Gadw mewn:
Prif Awduron: Xiaoying Zhao, Kunli Qu, Benedetta Curci, Huanming Yang, Lars Bolund, Lin Lin, Yonglun Luo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2023-05-01
Cyfres:Biomolecules
Pynciau:
gene editing
CRISPR
Cas9
prime editing
DMD
gene therapy
Mynediad Ar-lein:https://www.mdpi.com/2218-273X/13/5/870
Tagiau: Ychwanegu Tag
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