JCV-specific cell-based assays for PML risk assessment in lupus and multiple sclerosis patients with and without natalizumab

BackgroundProgressive multifocal leukoencephalopathy (PML) is an opportunistic infection caused by the JC virus and often fatal. Natalizumab is a highly effective therapy for multiple sclerosis (MS) but is linked to a high incidence of PML. The current metrics used to stratify MS patients at risk fo...

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Autors principals:	Qi Wu, Elizabeth A. Mills, Qin Wang, Guangmei Mao, Yang Mao-Draayer
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-08-01
Col·lecció:	Frontiers in Neurology
Matèries:	PML DMT MS cytotoxicity index OX40 immunity index natalizumab (Tysabri)
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1584083/full
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