CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain

The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the amyloid-β (Aβ) peptides, involved in Alzheimer’s Disease (AD). Other substrates of the γ-secretase, such as E-cadherin and Notch1,...

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Bibliografische Detailangaben

Hauptverfasser:	Noemi Monti, Rosaria A. Cavallaro, Andrea Stoccoro, Vincenzina Nicolia, Sigfrido Scarpa, Gabor G. Kovacs, Maria Teresa Fiorenza, Marco Lucarelli, Eleonora Aronica, Isidre Ferrer, Fabio Coppedè, Aron M. Troen, Andrea Fuso
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2020-08-01
Schriftenreihe:	Epigenetics
Schlagworte:	presenilin1 dna methylation non-cpg methylation mips (non-cpg methylation-insensitive primers) alzheimer’s disease neurodevelopment neurodegeneration
Online-Zugang:	http://dx.doi.org/10.1080/15592294.2020.1722917
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