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Exosomes derived from miR-146a-overexpressing fibroblast-like synoviocytes in cartilage degradation and macrophage M1 polarization: a novel protective agent for osteoarthritis?

IntroductionPathological changes in the articular cartilage (AC) and synovium are major manifestations of osteoarthritis (OA) and are strongly associated with pain and functional limitations. Exosome-derived microRNAs (miRNAs) are crucial regulatory factors in intercellular communication and can inf...

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Autori principali: Huan Wang, Yue Zhang, Chengfei Zhang, Yan Zhao, Jun Shu, Xuezhang Tang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-05-01
Serie:Frontiers in Immunology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1361606/full
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