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Putative Autoantigen Leiomodin-1 Is Expressed in the Human Brain and in the Membrane Fraction of Newly Formed Neurons

Nodding syndrome is a pediatric epilepsy disorder associated with <i>Onchocerca volvulus</i> infection, but the mechanism driving this relationship is unclear. One hypothesis proposes that parasite-induced immune responses cross-react with human leiomodin-1 resulting in immune-mediated central nervo...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: David W. Nauen, Michael C. Haffner, Juyun Kim, Qizhi Zheng, Hao Yin, Angelo M. DeMarzo, Vasiliki Mahairaki, Carlo Colantuoni, J. Geoffrey Pickering, Tory P. Johnson
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-12-01
Schriftenreihe:Pathogens
Schlagworte:
nodding syndrome
leiomodin-1
autoantibody
CNS
neuron
membrane
Online-Zugang:https://www.mdpi.com/2076-0817/9/12/1036
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