Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel miss...

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Principais autores:	Mónica Fernández-Cancio, Núria Camats, Christa E. Flück, Adam Zalewski, Bernhard Dick, Brigitte M. Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V. Pandey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2018-04-01
coleção:	Pharmaceuticals
Assuntos:	P450c17 prostate cancer abiraterone steroidogenesis androgens dehydroepiandrosterone CYP17A1 cytochrome P450 anti-cancer drugs DSD
Acesso em linha:	http://www.mdpi.com/1424-8247/11/2/37
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