High-Order Epistasis and Functional Coupling of Infection Steps Drive Virus Evolution toward Independence from a Host Pathway
ABSTRACT The phosphatidylinositol-4 kinase IIIβ (PI4KB)/oxysterol-binding protein (OSBP) family I pathway serves as an essential host pathway for the formation of viral replication complex for viral plus-strand RNA synthesis; however, poliovirus (PV) could evolve toward substantial independence from...
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2021-10-01
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| Collection: | Microbiology Spectrum |
| Sujets: | |
| Accès en ligne: | https://journals.asm.org/doi/10.1128/Spectrum.00800-21 |
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