Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer

Abstract Accumulating evidence indicates that evasion of apoptosis and metabolic reprogramming are necessary for pancreatic cancer growth, early invasion, and chemotherapeutic resistance. Building on our prior work, we investigated the anti-tumor potential of a rationally designed mitochondria-targe...

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Detalhes bibliográficos

Principais autores:	Maria Poimenidou, Jordan M. Bobek, Donovan Drouillard, Tyler Harris, Elisabeth Solis, Chad Darnell, Donna McAllister, Robert F. Keyes, Mayumi Ishihara-Aoki, Kazuhiro Aoki, Daisy Sahoo, Balaraman Kalyanaraman, Brian C. Smith, Michael B. Dwinell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-05-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-026-08859-y
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