The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress
Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal proteins RPL5 and RPL11. Here, we report that R...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2013-10-01
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| Serier: | Cell Reports |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2211124713005093 |
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